In colorectal cancer (CRC), Notch1 signaling is a major pathway that governs cancer cell differentiation and proliferation. Its dysregulation is associated with CRC pathogenesis, the second leading cause of cancer death among US men and women combined. Although recent advances...

In colorectal cancer (CRC), Notch1 signaling is a major pathway that governs cancer cell differentiation…

Medical Sciences, Therapeutics

Endoscopic ultrasound (EUS)-guided chemoablation is an innovative, minimally invasive, and rapidly evolving technique that can be used for treatment of mucinous (precancerous) type pancreatic cysts, but there is currently no standardized device available to provide reliable and...

Endoscopic ultrasound (EUS)-guided chemoablation is an innovative, minimally invasive, and rapidly evolving technique that can…

Medical Devices, Medical Sciences

Leveraging a versatile and biocompatible citrate-based material platform, researchers have developed a high-strength, elastic and kink resistant, rapidly degradable biphasic catheter. The citrate-based elastomer material swells when surrounded by body fluid, anchoring the...

Leveraging a versatile and biocompatible citrate-based material platform, researchers have developed a high-strength, elastic and…

Chemistry & Materials, Engineering & Materials, Medical Sciences

The Flap Jack is a disposable, self-retaining surgical retractor that allows operation with a single hand. It is comprised of an upper and lower flat blade, interconnected by an expanding elastic design. It is inserted through incision into the breast pocket and advanced as...

The Flap Jack is a disposable, self-retaining surgical retractor that allows operation with a single…

Medical Devices, Medical Sciences

A thin, flexible, bioabsorbable material, galactomannan film has been developed that can be paired with biocompatible conductors to create sensors suitable for on or inside the human body. The thin, flexible sensors can conform to the body and collect biometrics over time, with...

A thin, flexible, bioabsorbable material, galactomannan film has been developed that can be paired with…

Medical Devices, Medical Sciences

Adeno-associated viruses (AAV) are common gene therapy vectors. However, AAV transgene packaging is usually imperfect. Despite continuing efforts to improve yield, the persistence of unpackaged virions remains a major challenge for efficient AAV vector production. Empty capsids...

Adeno-associated viruses (AAV) are common gene therapy vectors. However, AAV transgene packaging is usually imperfect.…

Engineering & Materials, Medical Sciences, Other Medical Technology, Research Tools & Devices

Viral infections continue to represent major challenges to public health, and an enhanced mechanistic understanding of the processes that contribute to the viral life cycle is necessary for the development of new therapeutic strategies. Inventors at the Albert Einstein College...

Viral infections continue to represent major challenges to public health, and an enhanced mechanistic understanding…

Medical Sciences, Therapeutics

Low Cost Haptic Force Needle Insertion Simulator (LCNIS) allows users to effectively train for steady hand motion upon instrument insertion, which is a critical skill for numerous medical procedures. Other training devices exist including mannequins and inexpensive homemade...

Low Cost Haptic Force Needle Insertion Simulator (LCNIS) allows users to effectively train for steady…

Medical Devices, Medical IT, Medical Sciences

This technology, referred to as Torso Assist Ventilation (TAV), comprises an assembly of reinforced silicone tubes that encircle and adhere to a patient’s chest and abdomen. When pneumatically activated, the TAV device provides an expansion force that distends the torso. This...

This technology, referred to as Torso Assist Ventilation (TAV), comprises an assembly of reinforced silicone…

Medical Devices, Medical Sciences

The PIGN gene is a cancer chromosomal instability (CIN) suppressor. Pu’s lab screened 48 MDS/AML patient samples and identified a novel PIGN gene mutation pattern responsible for increased genomic instability and subsequent myelodysplastic syndromes (MDS) transformation to acute...

The PIGN gene is a cancer chromosomal instability (CIN) suppressor. Pu’s lab screened 48 MDS/AML…

Medical Diagnostics, Medical Sciences

Diabetes often presents with systemic ocular surface complications including dry eye, keratopathy, and eye sensitivity. Studies have indicated 54% prevalence of asymptomatic and symptomatic Dry Eye Syndrome in diabetes. Penn State inventors have demonstrated that dysregulation...

Diabetes often presents with systemic ocular surface complications including dry eye, keratopathy, and eye sensitivity.…

Medical Sciences, Therapeutics

Despite current treatments, acute myeloid leukemia (AML) remains a fatal disease with a 5-year survival rate of less than 30%. Multi-kinase inhibitor midostaurin and dual FLT3/AXL inhibitor gilteritinib were approved by the FDA for the treatment of AML with FLT3 mutation....

Despite current treatments, acute myeloid leukemia (AML) remains a fatal disease with a 5-year survival…

Medical Sciences, Therapeutics

Researchers have discovered that GRK2 plays a central role in osteoarthritis development and that the clinically used depressant, paroxetine, ameliorates osteoarthritis development by inhibiting GRK2. Paroxetine is a disease-modifying agent that prevents cartilage degeneration,...

Researchers have discovered that GRK2 plays a central role in osteoarthritis development and that the…

Medical Sciences, Therapeutics

Previous efforts to develop high power, tunable, 2-5 µm fiber lasers have been compromised by thermal loss and alignment issues with the fibers. Bulk TM2+:ZnSe lasers have been limited by the large thermo-optic coefficient of ZnSe, which leads to thermal lensing and mode...

Previous efforts to develop high power, tunable, 2-5 µm fiber lasers have been compromised by…

Chemistry & Materials, Engineering & Materials, Other Engineering Technology, Semiconductor & Electronics

MicroRNAs (miRs) are particularly promising markers of disease due to their long-term stability and bioavailability in serum, urine, and saliva. This technology utilizes a set of miRs as diagnostic biomarkers to identify high-grade squamous intraepithelial lesions (HSIL) in Pap...

MicroRNAs (miRs) are particularly promising markers of disease due to their long-term stability and bioavailability…

Medical Diagnostics, Medical Sciences

Inventors have created a second-generation microfluidic device that allows for single cell isolation and analysis. The microfluidic device has been designed to be compatible with and mount easily to commonly available inverted microscopes. The device includes five independent...

Inventors have created a second-generation microfluidic device that allows for single cell isolation and analysis.…

Engineering & Materials, Medical Devices, Medical Diagnostics, Medical Sciences, Research Tools & Devices

Existing microscope optics make tradeoffs between the field of view and resolution. At the same time, modern CMOS sensors have reached over 100 million pixels in a single chip, well beyond the amount of information that can be recovered digitally with existing microscope optics....

Existing microscope optics make tradeoffs between the field of view and resolution. At the same…

Chemistry & Materials, Engineering & Materials, Medical Sciences, Other Medical Technology, Research Tools & Devices

The aldehyde dehydrogenases (ALDHs) are a family of detoxifying enzymes that are overexpressed in various cancers. Researchers have developed a novel, broad-spectrum, small molecule ALDH inhibitor, KS100. Enzymatic IC50s of KS100 were 207, 1,410, and 240 nM towards ALDH1A1, 2,...

The aldehyde dehydrogenases (ALDHs) are a family of detoxifying enzymes that are overexpressed in various…

Medical Sciences, Therapeutics