DNA methylation motifs identify potential epigenetic regulatory functionalities. The invention comprises a computational heuristic to identify the potential genomic-word-framework (GWF) regions. The inventors employed a programming language for methylation analyses and GWF...

DNA methylation motifs identify potential epigenetic regulatory functionalities. The invention comprises a computational heuristic to…

Artificial Int. & Machine Learning, Crop Improvement & Management, Databases & Data Mining, Medical Diagnostics

Gram-negative bacteria are formidable pathogens because their cell envelope presents an adaptable barrier to environmental and host-mediated challenges. The stress response pathway, controlled by the alternative sigma factor sE, is critical for maintenance of the cell envelope....

Gram-negative bacteria are formidable pathogens because their cell envelope presents an adaptable barrier to environmental…

Medical Sciences, Therapeutics

The researchers have produced robust graphene oxide (GO) fibers with complex architectures and exceptional mechanical and electrical properties. The GO fibers have extremely large elongation to fracture (up to 76%), high toughness (up to 17 J/m3), and attractive macroscopic...

The researchers have produced robust graphene oxide (GO) fibers with complex architectures and exceptional mechanical…

Medical Devices, Medical Diagnostics, Medical Sciences

Penn State researchers have developed micro/nanoobjects in the form of micro/nanorods that, when contained within a catalytic zone of a dilute aqueous solution, react by exhibiting anisotropic motion without the presence of an external energy source. By converting chemical...

Penn State researchers have developed micro/nanoobjects in the form of micro/nanorods that, when contained within…

Engineering & Materials, Medical Devices, Medical Diagnostics, Medical Sciences, Research Tools & Devices

The inventors modified commercial processes to controllably and economically manufacture two-dimensional and three-dimensional, reproducible patterned surfaces of microstructures to create structural colors at a lower production costs than nanoscale materials. The inventors...

The inventors modified commercial processes to controllably and economically manufacture two-dimensional and three-dimensional, reproducible patterned…

Advanced Manufacturing (e.g. additive), Chemistry & Materials, Engineering & Materials, Misc Manufactured Articles

A system for the generation of attack-resistant, user-friendly, image-based CAPTCHAs. Controlled distortions are produced on randomly chosen images and present them to the user in the form of a mosaic. The images are distorted in a way that precludes the use of...

A system for the generation of attack-resistant, user-friendly, image-based CAPTCHAs. Controlled distortions are produced on…

IT & EdTech, IT Security

Inventors have created a second-generation microfluidic device that allows for single cell isolation and analysis. The microfluidic device has been designed to be compatible with and mount easily to commonly available inverted microscopes. The device includes five independent...

Inventors have created a second-generation microfluidic device that allows for single cell isolation and analysis.…

Engineering & Materials, Medical Devices, Medical Diagnostics, Medical Sciences, Research Tools & Devices

Spreading depression or depolarization (SD) is a large-scale pathological brain phenomenon related to migraines, stroke, hemorrhage and traumatic brain injury. SD manifests as a slow (2-5 mm/min) traveling wave front of neuronal depolarization. SD propagates across grey matter...

Spreading depression or depolarization (SD) is a large-scale pathological brain phenomenon related to migraines, stroke,…

Medical Devices, Medical Sciences, Therapeutics

Viral infections continue to represent major challenges to public health, and an enhanced mechanistic understanding of the processes that contribute to the viral life cycle is necessary for the development of new therapeutic strategies. Inventors at the Albert Einstein College...

Viral infections continue to represent major challenges to public health, and an enhanced mechanistic understanding…

Medical Sciences, Therapeutics

Liquid formulations of therapeutic proteins require storage at high concentration and must remain stable for 2 years for FDA approval. Drug formulation is hindered by slow and inaccurate tests for predicting a drug’s shelf life. This technology offers high-throughput and...

Liquid formulations of therapeutic proteins require storage at high concentration and must remain stable for…

Engineering & Materials, Medical Devices, Medical Sciences, Research Tools & Devices, Transportation Technologies

The inventors identified promising boron-based compounds that trap phosphatases from the LAR/PTP-sigma/PTP-delta subfamily of the transmembrane PTP. These phosphatases play a role in neuronal development and path finding; they are potential targets for diabetes treatment. These...

The inventors identified promising boron-based compounds that trap phosphatases from the LAR/PTP-sigma/PTP-delta subfamily of the…

Medical Sciences, Therapeutics

The researchers have developed methods and compositions of matter relating to inhibitors of the tmRNA pathway. These potential therapeutics have antibacterial activity with broad species specificity, including B. anthracis and other pathogens of military and civilian interest....

The researchers have developed methods and compositions of matter relating to inhibitors of the tmRNA…

Medical Sciences, Other Medical Technology, Therapeutics

With the development of CRISPR/Cas9-mediated gene editing technologies, correction of disease-causing mutations has become possible. However, current CRISPR technologies have a number of shortcomings. For example, current gene correction strategies preclude mutation repair in...

With the development of CRISPR/Cas9-mediated gene editing technologies, correction of disease-causing mutations has become possible.…

Medical Sciences

Viruses exploit host cells to produce viral proteins to replicate and infect other cells. The need to produce viral proteins leave viruses susceptible to exploitation by defective versions of themselves. A defective viral genome with deletions in protein-coding genes can...

Viruses exploit host cells to produce viral proteins to replicate and infect other cells. The…

Medical Sciences, Therapeutics

Adeno-associated viruses (AAV) are common gene therapy vectors. However, AAV transgene packaging is usually imperfect. Despite continuing efforts to improve yield, the persistence of unpackaged virions remains a major challenge for efficient AAV vector production. Empty capsids...

Adeno-associated viruses (AAV) are common gene therapy vectors. However, AAV transgene packaging is usually imperfect.…

Engineering & Materials, Medical Sciences, Other Medical Technology, Research Tools & Devices

Crosstalk is a major issue in optical fiber bundles caused by optical fibers being brought very close together thus limiting the capacity or resolution. The proposed invention presents a way to minimize crosstalk by selecting the radii of the fibers in a fractal pattern. The...

Crosstalk is a major issue in optical fiber bundles caused by optical fibers being brought…

IT & EdTech, IT Networking & Communications, Medical Devices, Medical Sciences

A novel scaffold has been created composed of 60 self-assembling protein subunits, rigid, heat stable, and can be functionalized via modification to the N-and C- term of each subunit. The inventors generated two novel variations of the cage – SpyCage-Green/Red/Blue and...

A novel scaffold has been created composed of 60 self-assembling protein subunits, rigid, heat stable,…

Engineering & Materials, Medical Sciences, Other Medical Technology, Research Tools & Devices, Therapeutics

Basal levels of autophagy affect lifespan and loss of autophagy leads to neurodegeneration. Heparan sulfate (HS) proteoglycans are abundant carbohydrate-modified proteins found on cell surfaces and in the extracellular matrix. Results implicate HS as a suppressor of autophagy...

Basal levels of autophagy affect lifespan and loss of autophagy leads to neurodegeneration. Heparan sulfate…

Medical Sciences, Therapeutics