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Nontoxic Compounds for Treatment and Prevention of Herpesvirus

ID# 2016-4468
Structure of Retro94

Technology Summary

Inventors have developed a compound, Retro94, that inhibits human cytomegalovirus (HCMV) replication with high potency and low toxicity. in vitro, the compound was shown to reduce production of infectious virions by greater than two fold.

Application & Market Utility

Current treatments for HCMV suffer limitations. Foscarnet and Cidofovir are potent polymerase inhibitors that are not specific to viral polymerases causing high toxicity. HCMV has developed resistance to Ganciclovir. Novel approaches are required to effectively fight HCMV.

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