Diagram of Pancreatic Cancer
Pancreatic cancer (PC) is one of the deadliest cancers, with a median survival of six months and a five year survival rate of only 3-5%, since current chemotherapy is not satisfactory. Through extensive SAR studies on NSAID compounds, we have recently identified a cyclic Se-Aspirin compound, AS-10, designed by incorporating selenazole into acetylsalicylic acid structure, rendering it lethal to cancer cells.
Application & Market Utility
AS-10 is 100 times more potent than gemcitabine, the first-line drug for PC, in killing PC cells. AS-10 was selectively toxic to cancer cells, induced apoptosis, and inhibited tumor growth in a colon cancer xenograft mouse model without any apparent systemic toxicity. In addition to cancer treatment, the AS-10 is useful for patients taking aspirin daily for heart disease and likely useful as an NSAID for pain, fever, and inflammation, while eliminating aspirin related gastrointestinal bleeding issues due to a ~100 times lower dose requirement.
Patent 10,287,259 issued 5/14/2019. Seeking licensing opportunities. Perform human trials.