Sculptured Thin Films to Control Cellular ProcessesID# 2005-3144
The disclosed invention entails polymeric sculptured thin films of nanoscale topography. The films feature porous, three-dimensional textures at both the nanoscale and microscale thereby promoting cell adhesion, proliferation, and differentiation. They are made of biocompatible materials and are formed by physical and chemical vapor deposition – no masks are needed. One may coat the films in strips, sheets, or on prefabricated polymeric and inorganic parts.
Application & Market Utility
Controlling cellular proliferation, differentiation, and adhesion is essential for many biotech applications. One may presently achieve such control with sculptured thin films of microscale topography and these films can be functionalized to promote cellular processes. However, the materials comprising these films are frequently incompatible with cellular matter (silicon rapidly degrades when interacting with biofluids).
Seeking research collaboration and licensing opportunities.