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Stimuli-Responsive Peptide Nanoparticles

ID# 2017-4626
Invention design and delivery mechanism

Technology Summary

The present invention is a drug delivery vehicle that uses nanoparticles that can be activated via ultrasound (US) to deliver membrane-impermeable cargo directly into cells with spatial and temporal precision. Key to the formation of these particles is a synthetic peptide designed to self-assemble at the surface of a US-sensitive liquid droplet. Utilizing peptide assembly allows for cell-targeted, cargo-loaded nanoparticles to be prepared in a single and mild synthetic step that is conducive to sensitive biomolecules, which is in stark contrast to existing stimuli- responsive and cell-targeted nanoparticle carriers. The invention exploits a physical US cavitation phenomenon to rupture non-peptisomes and affords direct delivery of loaded cargo into cells, thereby completely avoiding endocytosis.

Application & Market Utility

This invention provides a mechanism to deliver biotherapeutics directly to the cytoplasm of a diseased cell. Therefore, the present technology could have applicability to vast market needs, such as treatment of cancer, autoimmune disorders, inflammatory diseases, diabetes, cardiovascular diseases, etc. Specifically, the technology can could be used as a carrier for site- specific delivery of biosensors, genome editing tools, diagnostic agents, or membrane impermeable therapeutics, such as antibodies.

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