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Versatile Display Scaffold for Cryo-TEM Imaging and Analysis

ID# 2017-4583
Nanocage Scaffold

Technology Summary

Cryogenic electron microscopy (cryo-EM) has changed the landscape of structural biology. Advances in cryo-EM software, hardware, instrumentation, and data collection now permit high resolution structural solutions of proteins that are not amenable to NMR or crystallographic methods. However, these incredible breakthroughs have largely been restricted to proteins and complexes that are large (>200kD), hydrophilic, and often symmetrical. To overcome these limitations, Penn State inventors have developed a versatile molecular platform that can enable cryo-EM approaches for previously poorly behaved specimens, including small proteins and therapeutic small molecules.

Application & Market Utility

These protein scaffolds can be sold in a “plug-and-play” kit format, either individually or as a panel of scaffold reagents, that enables users to try different variants to optimize the conditions for their specific application: addressing problems with aggregation, sample spread across the grid, overcoming preferred orientations, and display of membrane proteins. The primary intent of these reagents is as display scaffolds for electron microscopy purposes. They may have follow-on applications in antibody production, or the treatment of human disease.

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