A searchable showcase of Penn State’s top emerging technologies available for licensing
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One-step Instrument-free High-affinity Aptamer Selection
ID# 2022-5492
The inventors have developed a Hydrogel for Aptamer Selection (HAS) method for fast, reliable aptamer selection in one single step with a virtually 100% success rate. Aptamers, also known as…
The inventors have developed a Hydrogel for Aptamer Selection (HAS) method for fast, reliable aptamer…
Engineering & Materials, Medical Sciences
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Bioactive Granular Hydrogel Scaffolds and the Use Thereof
ID# 2022-5462
New technology has been created to convert protein-based materials into stable microgels and assemble them into granular hydrogel scaffolds (GHS) without the need for light exposure. This non-invasive approach allows…
New technology has been created to convert protein-based materials into stable microgels and assemble them…
Medical Sciences
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Novel Small Molecule Inhibitor of Notch1 Activation
ID# 2019-5009
In colorectal cancer (CRC), Notch1 signaling is a major pathway that governs cancer cell differentiation and proliferation. Its dysregulation is associated with CRC pathogenesis, the second leading cause of cancer…
In colorectal cancer (CRC), Notch1 signaling is a major pathway that governs cancer cell differentiation…
Medical Sciences, Therapeutics
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System And Method For Fastening A Tubular Prosthesis
ID# 2021-5236
The use of handsewn anastomosis is common when replacing and resecting the aorta, as mortality with non-operative therapy is very high, but the dissection disrupts normal tissue integrity, making the…
The use of handsewn anastomosis is common when replacing and resecting the aorta, as mortality…
Medical Sciences
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EUS-Guided Chemoablation of Pre-Cancerous Pancreatic Cysts
ID# 2020-5103
Endoscopic ultrasound (EUS)-guided chemoablation is an innovative, minimally invasive, and rapidly evolving technique that can be used for treatment of mucinous (precancerous) type pancreatic cysts, but there is currently no…
Endoscopic ultrasound (EUS)-guided chemoablation is an innovative, minimally invasive, and rapidly evolving technique that can…
Medical Devices, Medical Sciences
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Biodegradable and Multifunctional Neural Block Devices
ID# 2020-5077
Leveraging a versatile and biocompatible citrate-based material platform, researchers have developed a high-strength, elastic and kink resistant, rapidly degradable biphasic catheter. The citrate-based elastomer material swells when surrounded by body…
Leveraging a versatile and biocompatible citrate-based material platform, researchers have developed a high-strength, elastic and…
Chemistry & Materials, Engineering & Materials, Medical Sciences
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Flap Jack Surgical Retractor
ID# 2015-4335
The Flap Jack is a disposable, self-retaining surgical retractor that allows operation with a single hand. It is comprised of an upper and lower flat blade, interconnected by an expanding…
The Flap Jack is a disposable, self-retaining surgical retractor that allows operation with a single…
Medical Devices, Medical Sciences
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Low Cost Disposable Sensors for Biomedicine
ID# 2018-4723
A thin, flexible, bioabsorbable material, galactomannan film has been developed that can be paired with biocompatible conductors to create sensors suitable for on or inside the human body. The thin,…
A thin, flexible, bioabsorbable material, galactomannan film has been developed that can be paired with…
Medical Devices, Medical Sciences
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Sensitive Methods for Measuring Proportion of Genome-filled AAV Vector
ID# 2019-4892
Adeno-associated viruses (AAV) are common gene therapy vectors. However, AAV transgene packaging is usually imperfect. Despite continuing efforts to improve yield, the persistence of unpackaged virions remains a major challenge…
Adeno-associated viruses (AAV) are common gene therapy vectors. However, AAV transgene packaging is usually imperfect.…
Engineering & Materials, Medical Sciences, Other Medical Technology, Research Tools & Devices
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A Novel Broad-Spectrum Viral Inhibitor
ID# 2017-4657
Viral infections continue to represent major challenges to public health, and an enhanced mechanistic understanding of the processes that contribute to the viral life cycle is necessary for the development…
Viral infections continue to represent major challenges to public health, and an enhanced mechanistic understanding…
Medical Sciences, Therapeutics
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Low Cost Haptic Force Needle Insertion Simulator
ID# 2017-4587
Low Cost Haptic Force Needle Insertion Simulator (LCNIS) allows users to effectively train for steady hand motion upon instrument insertion, which is a critical skill for numerous medical procedures. Other…
Low Cost Haptic Force Needle Insertion Simulator (LCNIS) allows users to effectively train for steady…
Medical Devices, Medical IT, Medical Sciences
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Torso Assist Ventilation (TAV) Device for Preterm Newborns, Children, and Adults
ID# 2016-4502
This technology, referred to as Torso Assist Ventilation (TAV), comprises an assembly of reinforced silicone tubes that encircle and adhere to a patient’s chest and abdomen. When pneumatically activated, the…
This technology, referred to as Torso Assist Ventilation (TAV), comprises an assembly of reinforced silicone…
Medical Devices, Medical Sciences
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Diagnostic Test to Identify Chromosomal Instability
ID# 2016-4434
The PIGN gene is a cancer chromosomal instability (CIN) suppressor. Pu’s lab screened 48 MDS/AML patient samples and identified a novel PIGN gene mutation pattern responsible for increased genomic instability…
The PIGN gene is a cancer chromosomal instability (CIN) suppressor. Pu’s lab screened 48 MDS/AML…
Medical Diagnostics, Medical Sciences
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Topical Naltrexone as a Treatment for Dry Eye
ID# 2008-3489
Diabetes often presents with systemic ocular surface complications including dry eye, keratopathy, and eye sensitivity. Studies have indicated 54% prevalence of asymptomatic and symptomatic Dry Eye Syndrome in diabetes. Penn…
Diabetes often presents with systemic ocular surface complications including dry eye, keratopathy, and eye sensitivity.…
Medical Sciences, Therapeutics
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Novel Combinatorial Therapy to Overcome Therapy Resistance in AML
ID# 2019-4982
Despite current treatments, acute myeloid leukemia (AML) remains a fatal disease with a 5-year survival rate of less than 30%. Multi-kinase inhibitor midostaurin and dual FLT3/AXL inhibitor gilteritinib were approved…
Despite current treatments, acute myeloid leukemia (AML) remains a fatal disease with a 5-year survival…
Medical Sciences, Therapeutics
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New Method of Synthesis for Cyclopropanes
ID# 2022-5543
Cyclopropane is a molecule that plays a key structural role in many natural products, preclinical, clinical, and commercial drugs. However, the current method of producing cyclopropane involves a highly energetic,…
Cyclopropane is a molecule that plays a key structural role in many natural products, preclinical,…
Chemistry & Materials, Other Medical Technology
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Ultrasound Responsive Hydrogels for Controlled Drug Delivery
ID# 2021-5214
Focused ultrasound has been demonstrated as a safe external stimulus that allows for deep tissue penetration while being nonionizing and noninvasive. This drug delivery system utilizes Dies-Alder linkers to cross-link…
Focused ultrasound has been demonstrated as a safe external stimulus that allows for deep tissue…
Engineering & Materials
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Granular Hydrogel Bioinks with Preserved Interconnected Microporosity and the Use Thereof
ID# 2022-5413
Three-dimensional (3D) bioprinting of granular hydrogels comprising discrete hydrogel microparticles, or microgels, may overcome the intrinsic structural limitations of poor cell penetration and oxygen transfer using specialized nanoparticles. The resulting…
Three-dimensional (3D) bioprinting of granular hydrogels comprising discrete hydrogel microparticles, or microgels, may overcome the…
Medical Sciences