A searchable showcase of Penn State’s top emerging technologies available for licensing
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Materials with Large Nonlinear Optical and Electro-Optical Performance
ID# 2022-5397
The inventors successfully grew large high-quality crystals having a chalcopyrite structure using a novel synthesis method that avoids using toxic chemicals. The uniaxial crystals exhibit a giant SHG coefficient of…
The inventors successfully grew large high-quality crystals having a chalcopyrite structure using a novel synthesis…
Chemistry & Materials, Medical Diagnostics, Semiconductor & Electronics
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New Method of Synthesis for Cyclopropanes
ID# 2022-5543
Cyclopropane is a molecule that plays a key structural role in many natural products, preclinical, clinical, and commercial drugs. However, the current method of producing cyclopropane involves a highly energetic,…
Cyclopropane is a molecule that plays a key structural role in many natural products, preclinical,…
Chemistry & Materials, Other Medical Technology
![Production of negatively charged hBN sheets from K-intercalated hBN.](https://invent.psu.edu/wp-content/uploads/2023/08/Untitled-design-15-330x165.png)
Methods of Preparing Alkali Metal-intercalated hBN Materials, Resultant Products and Uses Thereof
ID# 2021-5351
The invention covers a large-scale synthesis of alkali metal-intercalated hBN materials from heating and mixing a molten alkali metal with hBN powders. The method enables the efficient characterization of the…
The invention covers a large-scale synthesis of alkali metal-intercalated hBN materials from heating and mixing…
Energy & Environment
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Genomic Word Frameworks of Methylation Motifs for Predictive Modeling
ID# 2022-5368
DNA methylation motifs identify potential epigenetic regulatory functionalities. The invention comprises a computational heuristic to identify the potential genomic-word-framework (GWF) regions. The inventors employed a programming language for methylation analyses…
DNA methylation motifs identify potential epigenetic regulatory functionalities. The invention comprises a computational heuristic to…
Artificial Int. & Machine Learning, Crop Improvement & Management, Databases & Data Mining, Medical Diagnostics
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Novel Antibiotic Inhibitors
ID# 2020-5095
Gram-negative bacteria are formidable pathogens because their cell envelope presents an adaptable barrier to environmental and host-mediated challenges. The stress response pathway, controlled by the alternative sigma factor sE, is…
Gram-negative bacteria are formidable pathogens because their cell envelope presents an adaptable barrier to environmental…
Medical Sciences, Therapeutics
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Ultra-Tough Fibers and Films for Smart Textiles
ID# 2013-4145
The researchers have produced robust graphene oxide (GO) fibers with complex architectures and exceptional mechanical and electrical properties. The GO fibers have extremely large elongation to fracture (up to 76%),…
The researchers have produced robust graphene oxide (GO) fibers with complex architectures and exceptional mechanical…
Medical Devices, Medical Diagnostics, Medical Sciences
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Autonomous Moving Micro and Nanoobjects
ID# 2003-2760
Penn State researchers have developed micro/nanoobjects in the form of micro/nanorods that, when contained within a catalytic zone of a dilute aqueous solution, react by exhibiting anisotropic motion without the…
Penn State researchers have developed micro/nanoobjects in the form of micro/nanorods that, when contained within…
Engineering & Materials, Medical Devices, Medical Diagnostics, Medical Sciences, Research Tools & Devices
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Exfoliation and Dispersion of Carbon Nanothreads
ID# 2021-5329
The invention is a simple process of chemically activating the carbon nanothread crystals within a specific temperature range that produces a chemically activated carbon nanothread compound. The chemical activation of…
The invention is a simple process of chemically activating the carbon nanothread crystals within a…
Chemistry & Materials, Energy Devices (e.g. batteries), Medical Devices, Semiconductor & Electronics
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Manufacturing processe for microstructures producing structural colors
ID# 2020-5063
The inventors modified commercial processes to controllably and economically manufacture two-dimensional and three-dimensional, reproducible patterned surfaces of microstructures to create structural colors at a lower production costs than nanoscale materials.…
The inventors modified commercial processes to controllably and economically manufacture two-dimensional and three-dimensional, reproducible patterned…
Advanced Manufacturing (e.g. additive), Chemistry & Materials, Engineering & Materials, Misc Manufactured Articles
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Image-Based CAPTCHAs for Website Security
ID# 2005-3125
A system for the generation of attack-resistant, user-friendly, image-based CAPTCHAs. Controlled distortions are produced on randomly chosen images and present them to the user in the form of a mosaic.…
A system for the generation of attack-resistant, user-friendly, image-based CAPTCHAs. Controlled distortions are produced on…
IT & EdTech, IT Security
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Microfluidic Platform for Single Cell Analysis
ID# 2019-4912
Inventors have created a second-generation microfluidic device that allows for single cell isolation and analysis. The microfluidic device has been designed to be compatible with and mount easily to commonly…
Inventors have created a second-generation microfluidic device that allows for single cell isolation and analysis.…
Engineering & Materials, Medical Devices, Medical Diagnostics, Medical Sciences, Research Tools & Devices
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A Novel Broad-Spectrum Viral Inhibitor
ID# 2017-4657
Viral infections continue to represent major challenges to public health, and an enhanced mechanistic understanding of the processes that contribute to the viral life cycle is necessary for the development…
Viral infections continue to represent major challenges to public health, and an enhanced mechanistic understanding…
Medical Sciences, Therapeutics
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System and Method for Modulating Spreading Depression and State-based
ID# 2017-4681
Spreading depression or depolarization (SD) is a large-scale pathological brain phenomenon related to migraines, stroke, hemorrhage and traumatic brain injury. SD manifests as a slow (2-5 mm/min) traveling wave front…
Spreading depression or depolarization (SD) is a large-scale pathological brain phenomenon related to migraines, stroke,…
Medical Devices, Medical Sciences, Therapeutics
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System to Measure Stability of Concentrated Therapeutic Proteins
ID# 2016-4476
Liquid formulations of therapeutic proteins require storage at high concentration and must remain stable for 2 years for FDA approval. Drug formulation is hindered by slow and inaccurate tests for…
Liquid formulations of therapeutic proteins require storage at high concentration and must remain stable for…
Engineering & Materials, Medical Devices, Medical Sciences, Research Tools & Devices, Transportation Technologies
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Boronic Compounds for Use as Therapeutic Drugs
ID# 2015-4362
The inventors identified promising boron-based compounds that trap phosphatases from the LAR/PTP-sigma/PTP-delta subfamily of the transmembrane PTP. These phosphatases play a role in neuronal development and path finding; they are…
The inventors identified promising boron-based compounds that trap phosphatases from the LAR/PTP-sigma/PTP-delta subfamily of the…
Medical Sciences, Therapeutics
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tmRNA Inhibitors as Antibacterial Agents
ID# 2006-3177
The researchers have developed methods and compositions of matter relating to inhibitors of the tmRNA pathway. These potential therapeutics have antibacterial activity with broad species specificity, including B. anthracis and…
The researchers have developed methods and compositions of matter relating to inhibitors of the tmRNA…
Medical Sciences, Other Medical Technology, Therapeutics
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Strategies to Modify Arthropod Sperm to Achieve Cytoplasmic Incompatibility without Wolbachia
ID# 2024-5787
The inventors have established a method to alter host reproductive epigenetic pathway by using a chemical inhibitor molecule, Anacardic Acid, to induce CI without dependence of Wolbachia and other endosymbionts.…
The inventors have established a method to alter host reproductive epigenetic pathway by using a…
Animal Health & Management, Medical Sciences
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Compositions and Methods for Cytoplasmic Incompatibility Control of Arthropods
ID# 2024-5740
Wolbachia bacteria is known to effectively block virus replication in transmitting mosquitoes and rapidly spread itself in mosquito populations via a drive called cytoplasmic incompatibility (CI). Wolbachia-induced CI strength, however,…
Wolbachia bacteria is known to effectively block virus replication in transmitting mosquitoes and rapidly spread…
Medical Sciences